Can Animal Models of Disease Reliably Inform Human Studies?

نویسندگان

  • H. Bart van der Worp
  • David W. Howells
  • Emily S. Sena
  • Michelle J. Porritt
  • Sarah Rewell
  • Victoria O'Collins
  • Malcolm R. Macleod
چکیده

H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P115: A Novel High Tech Approach to Monitor the Pharmacotherapy of Alzheimer; a Narrative Review

Alzheimer's disease (AD) is multisystem and multifactor disease with a long no-symptom stage. We propose that a more effective approach to use fMRI as a still emerging, repeatable, non- invasive neuroimaging tools that can be very useful for evaluating, diagnosis, treatment and drugs- development. We studied 30 articles which published between 2008-2017 that included the effects of different bi...

متن کامل

P97: Physical Exercise as an Effective Factor in Alzheimer Disease

Alzheimer's disease (AD) is a progressive disease that destroys memory and other important mental activities. Scientists have found that remaining relatively active can lead to better brain activities in those at risk of developing AD. In some Meta-analyses of prospective investigations, a significantly reduced risk of dementia related to midlife exercise have been proven. Most studies have bee...

متن کامل

P119: Animal Models of Epilepsy: The Impact of some Chemoconvalsants on Animal Models

We summarize some of the most frequenthly used rodent animal models of temporal lobe epileps and the impact of chemoconvulsants on them. Temporal lobe epilepsy is the most common epilepsy in humans in which seizures spread to the neighboring cortiase and hippocampal neuron loss and other neuropathological take place. Temporal lobe epilepsy and the other form of epilepsy cannot acquired in chini...

متن کامل

A Review of Animal Models of Alzheimer\'s Disease: a brief insight to Pharmacologic and genetic models

Alzheimer's disease (AD) is the most common form of neurodegenerative disorders. Memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with AD. However, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to cure...

متن کامل

A New Model for Hendra Virus Encephalitis in the Mouse

Hendra virus (HeV) infection in humans is characterized by an influenza like illness, which may progress to pneumonia or encephalitis and lead to death. The pathogenesis of HeV infection is poorly understood, and the lack of a mouse model has limited the opportunities for pathogenetic research. In this project we reassessed the role of mice as an animal model for HeV infection and found that mi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2010